Acute and Subchronic Toxicity Assessment of Aerial Parts of Ferula persica in Female Mice

Authors

  • F Mojab Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • M Soleimani Far Pharmaceutical Sciences Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  • S Arbabi Bidgoli Department of Toxicology and Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Abstract:

Background: Ferula species have shown wide range of pharmacological properties but there is no study on oral safety profile of Ferula persica due to standard toxicology guidelines. Objective: This study aimed to evaluate the acute and subchronic oral toxicity of the alcoholic extract of the aerial parts of Ferula persica to provide its safe dose for long term oral administrations as a possible herbal remedy. Methods: Hydroalcoholic extract from leaves and flowers was provided and standardized then acute and repeated dose oral toxicity tests were performed by OECD 423 and 407 guidelines. In the subchronic test, animals in each treatment group received hydroalcoholic extracts 1000 mg/kg/day. At the end of study mortality, weight changes, biochemical, hematological and histopathological studies were performed. Results: Acute toxicity test did not show any mortality and any sign of toxicity up to 2000 mg/kg in a 14 days study and in the repeated dose toxicity test, no sign of organ toxicity was detected in doses up to 1000 mg/kg during 28 days continuous study according to clinical, hematological, biochemical and histopathological evidences in liver, kidney, uterus, ovaries, heart, lung and spleen of animals. Conclusion: This study has revealed the safety of Ferula persica herbal extract in acute and subchronic oral administrations in doses up to 2000 and 1000 mg/kg respectively. We have defined the limit of oral long term exposure (No Observed Adverse Effects Level /NOAEL) in doses up to 1000 mg/kg which could suggest these aerial parts of Ferula persica as a new herbal remedy for future medical and nutritional purposes.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Antihypoxic Activities of Aerial Parts and Roots of Ferula persica in Mice

 Background and purpose: Hypoxia occurs in ischemia and heart attack, and leads to death. It involves production of reactive oxygen species. Antioxidants exhibit antihypoxic properties. Ferula persica has distinctive antioxidant activities. Nothing is known about the protective effect of this plant against hypoxia-induced lethality in mice. Materials and methods: Protective effects of methanol...

full text

Acute and subchronic toxicity assessment model of Ferula assa-foetida gum in rodents.

AIM The present study was performed to investigate acute and subchronic oral toxicity of Ferula assa-foetida gum (28 days) in Sprague Dawley rats. MATERIALS AND METHODS Acute oral administration of F. assa-foetida was done as a single bolus dose up to 5 g/kg in mice and subchronic toxicity study for 28 days was done by oral administration at doses of 0 (control) and 250 mg/kg in Sprague Dawle...

full text

Evaluation of Acute and Subchronic Toxicity of Lagenaria Siceraria Aerial Parts

Lagenaria siceraria is traditionally being used in many countries in the treatment of various diseases including diabetes. The aim of the present study was to evaluate the safety of the methanol extract of L. siceraria aerial parts (MELS) through acute and subchronic toxicity study in mice. For acute toxicity study 5002000 mg/kg MELS were administered orally and obvious toxic symptoms and morta...

full text

Sesquiterpenes from aerial parts of Ferula vesceritensis.

From the dichloromethane extract of aerial parts of Ferula vesceritensis (Apiaceae), 11 sesquiterpene derivatives were isolated. Among them five were compounds designated as 10-hydroxylancerodiol-6-anisate, 2,10-diacetyl-8-hydroxyferutriol-6-anisate, 10-hydroxylancerodiol-6-benzoate, vesceritenone and epoxy-vesceritenol. The six known compounds were identified as feselol, farnesiferol A, lapido...

full text

Acute and subchronic toxicity assessment of Melastomastrum capitatum Fern. leaf methanol extract in Wistar albino rats

This study was carried in order to determine short-term (acute) and long-term(subchronic) effects of Melastomastrum capitatum leaf methanol extract in the management and treatment of certain diseases in traditional and complementary medicines  by many villages in Mambila Nigeria. Acute and subchronic toxicities were carried out in  accordance with the Organization for Economic Cooperation and D...

full text

Safety Assessment of Ocimum Basilicum Hydroalcoholic Extract in Wistar Rats: Acute and Subchronic Toxicity Studies

Objective(s) Ocimum basilicum L. is widely used in folk medicine of many countries including Iran. Both O. basilicum and its oil extract have received considerable attention for their potential medicinal properties, but there are a few reports about possible toxicity of this plant. Therefore, in the present study, acute and subchronic toxicity of O. basilicum hydroalcohlic extract have been ev...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 1  issue 69

pages  47- 58

publication date 2018-11

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023